Rare Cellular Functional Biomarkers by ELISPOTMonoclonal Antibodies
Rare Cellular Functional Biomarkers by ELISPOT
While standard endpoint ELISAs quantify bulk cytokine concentrations, they cannot determine the frequency of the individual cells producing them. We utilize advanced Enzyme-Linked ImmunoSpot (ELISPOT) platforms to deliver functional, single-cell resolution of immune responses. With an exceptional limit of detection reaching down to approximately 1 in 100,000 cells, this technology provides up to 100 times greater sensitivity than conventional ELISA.
Our bespoke assay services provide crucial biomarker data to drive confident decision-making across advanced biotherapeutic and vaccine pipelines:
Therapeutic Mode of Action (MoA):
Track real-time cellular responses from cytokine production to cytotoxicity to clearly define how a novel immunomodulatory agent interacts with the immune system.
Cell Therapy Characterization:
Evaluate the efficacy and tumor-specific T cell responses of adoptive cell therapies, including CAR-T and Tumor-Infiltrating Lymphocytes (TILs).
Preclinical Safety Biomarkers:
Utilize highly sensitive immune monitoring to assess potential immunotoxicity and immune-related adverse events during early drug development.
Cellular Immunogenicity Assessment:
Serve as the gold standard for enumerating antigen-specific T cells and B cells to accurately evaluate the magnitude and quality of vaccine-induced immune responses.
Durability & Immune Memory:
Quantify long-lived memory B cell and T cell responses to establish reliable biomarkers for long-term immunity and protection against reinfection.
Antigen & Adjuvant Screening
Efficiently screen large numbers of T cell epitopes and directly compare the functional effectiveness of different adjuvant formulations in driving desired Th1, Th2, or humoral responses.
