Sapidyne KinExa
Sapidyne KinExa
Our custom assay services leverage Sapidyne KinExA® (Kinetic Exclusion Assay) technology to provide unmodified, solution-phase measurements. This allows us to precisely characterize your most promising therapeutic candidates under true physiological conditions.
Antibody-Antigen Binding Affinity (Kd) Measurement:
Quantify true equilibrium dissociation constants for ultra-tight binders. This technology accurately measures affinities down to the picomolar level without solid-phase artifacts.
Binding Kinetics Characterisation (Kon/Koff):
Directly evaluate association and dissociation rates while molecules are free to move in solution.
Epitope Binding & Competition Analysis:
Determine distinct binding domains and evaluate steric hindrance through precise competition assay configurations.
Biotherapeutic Candidate Screening & Lead Selection:
Efficiently screen and rank-order multiple high-affinity clones. Advanced single-point screening methods offer improved throughput while maintaining strong correlations with full-curve equilibrium measurements.
Potency & Comparability Assessment for Biologics:
Establish rigorous batch-to-batch comparability profiles and active concentration baselines to ensure biotherapeutics consistently meet critical quality attributes throughout development.
